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Linus Pauling's correspondence with Alexander Rich: Dec. 9, 1952
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| Title | Linus Pauling's correspondence with Alexander Rich: Dec. 9, 1952 |
| Creator | Pauling, Linus, 1901-
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| Date | 1952-12-09 |
| Full Text | I suggest that you try to make well oriented fibers of sodium thymonucleate or other nucleic acid preparations by the use of plasticizers.
The fact that 50 percent relative humidity seems to be required to give good fibers suggests that substances containing hydroxyl groups would be satisfactory plasticizers. I think that you should try adding a little glycerine to the solution. Perhaps ethylene glycol or diethylene glycol would be worth trying. In fact, perhaps all of these substances should be added to the same preparation -- mixed plasticizers often are more effective than the individual plasticizers.
As to other substances, urea and salicylic acid and guanidium ion might all be worth trying.
There is the possiblity that dibutyl phthalate would be useful.
For one preparation you might try putting all of these things in the solution, with the nucleic acid, the plasticizers being added in rather small amounts.
I am asking Dr. Marsh to make a spectrometer investigation, and to calculate a radial distribution function. Would you turn over to him about 0.5 g of a preperation, for this purpose. If you powder photograph of the sodium thymonucleate taken directly from the bottle gives as good a powder photograph as the recrystallized material, I suggest that you give him a sample of the material from the bottel. Small amounts of impurities would not be important. |
| Subject | Nucleic acids
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| Object Type | Text |
| Material Format | text/plain |
| Transmission Data | Master file format: TIFF, 600 dpi, Epson GT-10000+ flatbed scanner. |
| Collection Series | Correspondence
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| Copyright | http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/copyright.html |
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